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It is often reversible, but if a person has been on a high dose for a long time, it isn't," he says.
The choice of an appropriate high dose for nonclinical toxicology studies continues to generate significant discussion and debate.
Of the 11 who received the drug for the entire 36 months, those who got the optimal dose — which was a high dose — for the whole time fared the best.
For treatment, coverslips of neurons were fed with fresh media and either ASO or scrambled control was immediately added to media at a concentration of 2.5 μM (low dose) or 10 μM (high dose) for ASO-1 or 8 μM for ASO-2 for 72 h, after which neurons were re-fed with fresh media.
It was reported that commercial MLT preparations contain six contaminants; four of them (MLT-formaldehyde condensation contaminants) are thought to be responsible for induction of oesinophilia when MLT was administered in a high dose for long time [10 12].
Hanssen classified antibiotic-loaded bone cement into high dose (>2 g antibiotic per 40 g cement) and low dose (<2 g antibiotic per 40 g cement) and recommended high dose for use as beads or spacers and low dose for prosthesis fixation [21].
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These charts, until recently, indicated dangerously high doses for methadone.
High doses for both drugs were representative of human treatments for severe psychosis.
"We just don't know what happens when people use high doses for long periods of time".
However, in the treatment of active influenza infection the drug is typically given at high doses for about one week.
Physical dependence may be produced after utilization of high doses for prolonged periods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com