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AuNP, at high dose also assumes magnetic moment [[22]] and this is in accordance with some of the positive high dose effect seen with AuNP.
In addition, Olive [ 39] reported that the high dose effect of MPEP can be due to mechanisms not associated with mGluR5 modulation.
It is widely accepted that the effect is a high dose effect of irritant chemicals or chemicals producing renal pelvic calcification as a result of imbalances in calcium metabolism, specific to the rat.
Meanwhile, the Oxford Survey of Childhood Cancers and surveys of nuclear workers show that at low dose levels the cancer risk is much greater than estimates based on atomic bomb survivors; the special association between leukemia and radiation is an exclusively high dose effect, and levels of radiosensitivity are much lower in the middle of the life span than at either extreme.
An increased recruitment of both PCNA and FEN-1 was detected in the presence of 4-AN (compare Figs. 3D and 3E with Figs. 4C and 4D), while no (low dose) or very little (high dose) effect of 4-AN treatment was seen for recruitment of XRCC1, POLβ, or PNK (data shown only for XRCC1).
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The higher amounts of ETOH consumed (which produce higher blood alcohol concentrations) may indicate that tolerance to the high dose effects of ETOH has developed with repeated deprivations.
DDTs are noted for their relatively high dose effects, causing a tremor syndrome in adult mice that includes hyperactivity, ataxia, and paralysis (Herr et al. 1985).
Future studies will be performed at lower levels to confirm there is no high-dose effect.
Although difficult to compare, the in vitro media and in vivo serum ClO4− concentrations suggest that the in vitro ClO4−-induced changes in organification may be a high-dose effect of ClO4−.
The presence of diffuse epithelial hyperplasia in the duodenum of mice could raise the question of whether tumorigenesis in this tissue was a high-dose effect resulting from Cr VI) cytotoxicity and subsequent compensatory proliferation.
The reasons may be found in a complex set of unrelated problems of which difficulties in replication of low-dose stimulatory responses resulting from poor study designs, greater societal interest in high-dose effects, linking of the concept of hormesis to the practice of homeopathy, and perhaps most crucially a complete lack of strong leadership to advocate its acceptance in the right circles.
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