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With the average age of patients about 70, most of the high-dose curative strategies exclude the bulk of patients affected by the disease.
Current curative strategies for relapsed patients are based on high dose cytotoxic therapy often followed by an allogeneic stem cell transplant.
Kurtzberg, J, Szabolcs, P, Howrey, RP, Driscoll, TA, and Martin, PL. "High dose chemotherapy followed by transplantation of unrelated, banked, umbilical cord blood provides curative therapy for young pediatric patients with familial erythrophagocytic lymphohistiocytosis fed". Blood 96, no.
Those on the high dose lost 10.6 percent.
Plus, a high dose of antibiotics.
Of note, high dose i.n.n
According to our protocol, patients with stage III-B NSCLC receive palliative radiotherapy and with stage III-A high-dose radiotherapy with curative intent.
High doses can cause fatal renal failure.
In high doses, aflatoxins can be deadly.
We know what happens at high doses.
High doses can cause cataracts.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com