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Application of the bi-directional coverage correction method II allowed us to determine the presence of 40 haplotypes, but such verification is laborious and raises concern regarding the acceptance of haplotypes characterized by high disproportion in forward and reverse strand counts.
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Doing such, MAD eliminates issues related to the possibility that a dominating element in the image affects the PCA components, with a disproportioned high variance compared to other elements of the image.
Although some technical and management challenges merit further investigation, the costs of delaying the use of HTA evidence-informed investment in the Global Fund are high given the severe disproportion between the current resources available and the need for prevention and control of three major disease burdens worldwide.
Such huge disproportion of positives and negatives instances determines a very high sparsity of the problem (density is less than 0.005), thus making the recommendation task particularly hard to solve with high accuracy.
That disproportion in high-profile positions reinforces popular suspicions that some old-boy network or entrenched sexism resists change.
In contrast, the rate of CS as a result of cephalo-pelvic disproportion was higher in secondary care than that in tertiary care hospitals (16.64% vs 13.01%, P < 0.001), which might have been due to a lower standard of medical technology in the secondary care setting compared with the tertiary care setting.
GBS resulted in a disproportion between the high number of scored markers for the mapping populations and population size.
Neonates with GOC often have a small underdeveloped peritoneal cavity with a high degree of viscera abdominal disproportion that can prohibit save primary closure.
Comparing the indications, 'abnormal presentation' and 'cephalic pelvic disproportion' contained the highest number of appropriate scenarios with agreement.
DOI: http://dx.doi.org/10.7554/eLife.03251.020 10.7554/eLiFigure51.021 Figure 7. High cooperativity does not explain the disproportion between trans -SNARE interaction and fusion rate resulting from HOPS addition.
Such a defect in bone quality could account for the higher incidence of fractures and the disproportion between the significant increase in bone fragility and the relative small decrease of BMD observed, for example, in glucocorticoid induced osteoporosis [ 12, 15].
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