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In the course of our investigations, we recognized that Voronoi diagrams work best in urban areas, which naturally feature a high density of cell sites.
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These results suggest that COOH- and NH2-SAMs allow for both cell adhesion and cell spreading because of the high density of cell-binding domains derived from adsorbed Vn.
(f) View of the amelanotic melanoma area showing high density of cells with no obvious sign of melanin.
High density of cells at 1.2 × 106 cells ml−1 was recorded after 4 days of culture.
Control biofilms show high density of cells with homogeneous shape (A).
After induced 6 h, the cell exposed to AHLs had a more homogeneous growth status, especially, there were high density of cells centralize on the medium level of FSC/SSC when cells were treated by 3OC6-HSL, however, the more cells in control showed decreased FSC and increased in SSC.
Accordingly, the bulges are formed of a high density of cells (Figures 8E 8F, 8M 8N) comparable to the density observed in the neuroepithelium.
A high density of cells allows simulation of a realistic tissue environment for dense tissues with high metabolic rates, such as liver.
One possibility is that the high density of cells used in previous studies [41] may alter intracellular signaling and the localization of transport factors.
Some top-down approaches have been developed to create artificial matrixes based on scaffolds with channels for nutrient delivery to enable culture at high density of cells [20], [21]; the present work focuses on a miniaturization strategy to allow culture at high densities of cells and integration with standard imaging and high-throughput tools.
S. acidocaldarius readily formed biofilms (25 35 µm thick) which contained a high density of cells and large aggregates, forming towering structures above the surface of attached cells (Fig. 3, first row).
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