In intermediate and high transmission areas, reduction in prevalence is short-lived and the probability of local elimination is low, even at high coverage levels of the intervention.
To avoid future outbreaks that can appear around imported cases of measles it is crucial to attain high coverage levels by timely vaccination.
Both the energy storage and back up system add an extra cost that has to be paid if such high coverage levels are a requirement.
The specificity of SPLINTER improved with higher coverage, whereas VarScan2 yielded more false positive results at high coverage levels, although this effect was abrogated by removing low-quality reads before variant identification.
The phenomenon is unique in that in the regime where the tunneling mechanism dominates, the diffusion rate is nearly temperature-independent. Vacancy diffusion can occur as the predominant method of surface diffusion at high coverage levels approaching complete coverage.
Additionally, for combinations with MSTBV at high coverage levels in low to moderate transmission settings elimination is approached, or achieved depending on the coverage level (Figure S6).
The message for control programs reliant on IRS is therefore that if IRS is used then it has to be at high coverage levels to be effective.
A more likely scenario is for incidence to be eventually reduced by 25 35% if high coverage levels are achieved (Figure 3).
The exceptions are in higher transmission settings for severe episodes averted by BSV with MSTBV, PEV alone and PEV with MSTBV, where very high coverage levels are associated with small reductions of effectiveness (Figure 9).
