When the network planner imposes multiple requirements (high coverage, low installation cost, and low exposure), more complex optimization algorithms are required.
However, seasonal IPT using community based health-workers has been piloted in several countries, and can achieve high coverage at moderate cost [35], [36].
Next generation sequencing (NGS) technologies[ 8] allow the comprehensive sequencing with high coverage at low cost resulting in millions of short reads.
With the media industry already reeling from a weak advertising market, Viacom, which owns the CBS television network, the MTV and Nickelodeon cable channels and the Paramount film studios, said higher news coverage costs at CBS News and its local television and radio stations would hurt the company's results.
A reduction in library size, while retaining high coverage, can reduce costs.
Based on the efficacy of the vaccines, the cost of vaccinations (including programme costs), the likelihood of achieving high coverage and the resulting cost-effectiveness for various groups, key public health bodies, including the World Health Organization (WHO), (World Health Organization, 2009) have recommended that highest priority be vaccinating girls before initiation of sexual activity.
It is vital that operators select base station locations so that efficiency is achieved, with high coverage relative to total cost of the selected operational base stations.
In our targeted enrichment experiments, we first evaluated a scalable multiplexed protocol for high coverage tNGS to investigate cost saving and quality control potential.
In contrast, in models with boosting (scenarios A and C), vaccination at high coverage is either not cost-effective within 180 years (scenario C) or cost-effective only on the very long term (> 130 years; scenario A), with exception of the first ten years after start of vaccination when varicella incidence is low and HZ incidence not yet increased.
While 454 shotgun pyrosequencing provided lower-cost, high coverage depth data without cloning biases, the addition of paired-end Sanger sequencing assisted resolving homopolymer regions and improved genome assemblies (Fig. S4).
This is an important step for showing the impact of higher coverage on costs and outcomes.
