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Until now, expression of various luciferases in plants required exogenous application of luciferins – frequently toxic and high-cost compounds – to achieve only temporary and relatively low light emission levels from live plant tissues [7].
Like dripping acid, the higher costs, compounded over time, eat away at returns.
The high cost is compounded by the fact that there is no sampling frame for MSM.
Dose-response experiments were not performed for rIberiotoxin or lolitrem B due to the high cost of these compounds.
To our knowledge, the biochemical effects of ω3 DPA have not been extensively studied in preclinical models due to the limited availability and high cost of pure compound.
Flavonoids and isoflavones are analysed as aglycones because of the high cost of the reference compounds or because some of them are not commercially available.
Therefore, using compounds with known biochemical mechanism of action and an established safety record for new purposes is an alternative to the high cost of de novo compound research [ 4].
Although rabies is preventable, the high cost of postexposure prophylaxis, compounded by the lack of education and awareness about rabies, limits use of postexposure prophylaxis in many developing countries.
"And the high cost of these bonds only compounds the injury to the state taxpayers".
This factor coupled with the high cost of production of synthetic compounds prompts further research for new antimicrobials that are effective against pathogens resistant to currently used drugs [ 21].
Although LC MS experiments using stable isotopically labeled compounds in combination with their naturally occurring pendants is already a well established and frequently used technique, the most limiting disadvantage is the relatively high cost associated with enrichment of compounds with some stable isotopes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com