Exact(1)
MSCs loaded with paclitaxel by exposure to high concentrations release the drug both in vitro and in vivo, inhibiting tumor proliferation.
Similar(7)
Conversely, blockers produce an inverted "U" shaped curve, where lower concentrations increase stimulated release, but at higher concentrations release returns to predrug levels and then often fall below predrug levels.
Thus, at least for Cd and Mn, the observed higher concentrations released from the smaller sized sediment with each treatment solution is not simply a function of these particles having higher concentrations available for release, but that these metals also are more readily released from the smaller sediment particles versus the larger.
The greater amount of vancomycin incorporated into PMMA should explain our findings of higher concentrations released over the early postoperative period, except for the first day.
In high concentrations, acutely released uric acid can crystallize in renal tubules, leading to renal insufficiency.
From the consistently high concentrations of released galacturonic acid, arabinose, and rhamnose, it can be deduced that all culture supernatants possess sufficient pectinase activity, even the N. crassa cultures which had a substantially lower activity.
Other anions were previously shown to cause, at high concentration, the release of PMP from the active site, for example, GSAM from pea leaves treated with 0.2 M phosphate at acidic pH [ 43].
By analogy, we considered here whether copper [oxo-]hydroxide adipate tartrate (CHAT) could be synthesised and formulated at high concentrations but still release copper ions at effective antimicrobial levels.
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