Sentence examples for high concentrations needed from inspiring English sources

First, the strong inhibition found at very low doses of galanin in the present study do not correlate with the high concentrations needed in vitro.

First, the team reasoned that the silk proteins were clumping because they weren't dissolving well enough in water at the high concentrations needed to properly spin silk.

Sensitive, IC50 reached with <0.78 µg/ml Mab; resistant, high concentrations needed (TriMab) or highest concentration not sufficient (4E10) to reach IC50; and moderately sensitive, with IC50 values in between (sensitive

Unfortunately, this approach was restricted by the high concentrations needed for in vivo effects [ 19].

The Z. mobilis GFOR is located in the periplasmic space where the high concentrations needed may occur.

Henriksen et al. [ 27] have previously shown that the high concentrations needed to observe inhibition in the cell-based acridine orange assay can lead to unclear results.

In contrast, truncation by DP4 inactivates CCL2 leading to a shift to higher concentrations needed to elicit chemotaxis (Fig 3 of Supporting Information).

Not least because the profoundly higher concentrations needed to achieve PDE4 inhibition, compared to those required for ACE inhibition, may serve also to uncover an emetic response in moexipril.

It is proposed that to reach the antimicrobial effect of caffeic acid much higher concentrations need to be used than are present in the tested seedcake extracts, as indicated by the effect of the 10 mg/ml concentration.

Our inability to detect a lower-affinity binding site may reflect the technical difficulties involved upon examination of binding at the high radioligand concentrations needed to define the low-affinity binding site.

We found that this change is associated with a reduced affinity of the antibody for human PDI (as indicated by higher serum concentrations needed to detect binding of the antibody to recombinant human PDI -see methods).