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A high centrality value of the neighbors should result in a high centrality for the node under consideration.
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Higher centrality for a gene indicates that the gene is more important to this network and should be more tightly related to breast cancer.
The high centrality of targeted proteins was correlated to their essentiality for viruses' lifecycle, using functional genomic RNAi data.
The most notable property of the pathway interaction networks for the glucose response at t = 2 is the high centrality of the Cytokine pathway.
The node colors indicated the eigen-value centrality, ranging from dark red for high centrality to dark blue for low centrality.
For genes with high centrality, eigenvector, degree and betweenness metrics achieve similar performances, whereas closeness centrality performs worse than them.
For instance, Bill Gates has high "centrality" not only because he has many friends, but because his friends are very important and connected themselves.
We find high centrality in these differentially induced genes, but not for the genes that are suppressed in cancer.
Notably, Prom+ genes have an unexpectedly high centrality when compared with a reference distribution (P = 0.008, for Eigenvalue centrality).
Genes essential for survival had previously been shown to exhibit high centrality in protein interaction networks.
Finally, for each of these networks, we calculated three centrality measures (degree, betweenness, closeness) of the genes in each network and then selected the genes with high centrality measures as described in the previous section.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com