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The application of the GenoType MTBDR plus assay has been reported in other high burden settings such as Russia, South Africa and China, but has not yet been reported from our setting [ 10, 15, 16].
Communal gathering places account for the majority of TB transmission in high burden settings.
Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person transmission in these communities is needed.
The diagnostic and prognostic relevance of IGRAs in high burden settings needs to be better characterised.
Data about the value of new diagnostic technologies are limited, particularly, in high burden settings.
This method is rapid and inexpensive and highly specific for Mycobacterium tuberculosis in high burden settings.
Similar(13)
It has low cross-contamination rates and is suitable for use in high-burden settings [9].
Unfortunately, in many high-burden settings, the paucity of laboratories equipped to perform routine culture and drug-susceptibility testing hampers efforts to document the extent of the problem.
Replacement of light microscopy with fluorescence microscopy would be one of the immediate options for improving TB case detection in high-burden settings.
Point-of-care diagnostics are desperately needed in high-burden settings in order to reduce delays in disease detection and to accelerate the recognition of treatment failure suggestive of drug-resistant tuberculosis [24].
This implies limited utility in high-burden settings where the prevalence of LTBI is usually high.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com