An evaluation of replicate microarrays showed the inherent variability of the LCM amplified microarrays to be marginally higher than found for bulk tissue Affymetrix microarrays (see Additional file 1).
Figure 3(a) (Media 1) and 3(b) (Media 2) compare the SV image quality with and without subpixel image registration realignment, clearly showing less bulk tissue signal and higher vascular contrast in the realigned image.
However, research efforts are necessary to minimize the artifacts due to vessel shadowing and bulk tissue motion to achieve high resolution imaging in large volume.
However, both require improvements to minimize the artifacts due to vessel shadowing and bulk tissue motion to achieve high resolution imaging in large volume.
Areas of flow are thus characterized by a low value of "randomness" after histogram equalization, whereas the bulk tissue is characterized by a high value.
Most soft tissues are considered to be elastomeric materials with high bulk modulus relative to Young's modulus, so the PR is expected to approximate 0.5 [ 15].
Laser capture microdissection (LCM) provides higher specificity in the selection of target cells compared to traditional bulk tissue selection methods, but at an increased processing cost.
This result reveals the passive diffusion limit of iodine observed in muscles and other tissues with a high partition coefficient (K d ) and a high bulk density (ρ b ).
However, at the highest afterload condition, markers of pathological hypertrophy and fibrosis were also upregulated, although the bulk tissue stiffness remained the same for all levels of applied afterload tested.
This effect is shown to be especially important in those tissues (e.g., muscles), which have a large partition coefficient (K d ), high bulk density (ρ b ), and low porosity.
