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A fully automated tactile stimulation was optimized in seven right-handed volunteers at 1.5 T for minimum scan time, high BOLD signals and robust localization of S2 by systematically varying the applied block-design.
The approach we have applied requires high BOLD imaging localization accuracy.
GO-based annotation results of CFinder andMCODE modules: High (bold font for every GO category), Medium (cor.mean ≧ 0.5), and Low (cor.mean < 0.5) confidence groups.
The time course of an image acquired at a very short echo time (TE1) was then used in a linear regression as a voxelwise regressor for the other image (i.e., the result of combining TE2, TE3, TE4, and TE5) in the same echo train acquired with high BOLD sensitivity.
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Moreover, high BOLD-responses were linked to longer RTs in a task-relevant bilateral fronto-cingulate-insular-parietal network.
A clinical functional magnetic resonance imaging (fMRI) protocol based on a fully automated tactile stimulation was optimized in 10 right-handed volunteers at 1.5 T for minimum scan time, high BOLD-signals and robust localization of the primary somatosensory cortex (S1) by systematically varying the applied block design.
In regions affected by magnetic field inhomogeneities, SE EPI provided significantly higher BOLD sensitivity than GE EPI.
Similarly, neuroimaging PET and fMRI studies found higher activation for visual stimuli in migraineurs [40 42], but recent reports showed that patients with aura show higher BOLD response to photic stimuli in contrasts to those migraineurs not experiencing aura symptoms [43, 44].
For the manual module (Figure 5), opposite patterns are predicted, with highest BOLD peaks occurring in the easier conditions.
In both cases, higher incongruencies will lead to a higher metabolic demand of these neurons, leading to a higher BOLD signal in fMRI, providing a possible explanation for our results that show increased incongruence increases cortical activation.
A quantitative comparison between activity in the two conditions within the confines of regions involved in gesture production however did reveal significantly higher BOLD during active guessing compared to passive viewing.
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