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The ligands are engineered with a new N‐terminus containing two isoleucine residues to provide an essential hydrophobic interphase for achieving high biologic activity.
The PDXs are stored frozen at early transplant generations in a resurrectable form, which eliminates continuous passaging in mice, thus ensuring maintenance of the high biologic and molecular fidelity and reproducibility of the models.
She had leukocytosis with neutrophilia, reactive thrombocytosis and high biologic inflammatory syndrome.
In fact, recent studies have established that DLBCL is associated with various genetic alterations and high biologic diversity.
However, important signals might be missed because relatively small changes in expression may be of high biologic and toxicologic relevance.
If the affinities between IL-11 and the two receptor subunits are in the same range, this would explain the high biologic activity of the H11 protein.
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Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications.
30 This suggests that an agent with less depth of tissue penetration but similar or higher biologic effect is needed to facilitate repeated dosing.
Some of the highest biologic concentrations of POPs measured in humans worldwide have been among Greenlandic Inuit (Danish Environmental Protection Agency 1997; Dewailly et al. 1999).
31– 34 In comparison to beta-emitting radioisotopes, radium- 223 (Ra; Alpharadin®, Algeta) is an α-emitter that delivers radiation with a higher biologic effect to a more localized area.
Furthermore, it may reflect a higher biologic activity of afatinib, an irreversible ErbB-family blocker, compared with other reversible agents that inhibit only one or two members of the HER family.
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