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The iron nanoparticles, which had a hydrodynamic diameter of 45 nm, showed high avidity for the integrin αvβ3 in a competitive binding assay.
In order to establish a specific and sensitive ELISA for ROS, a specific antibody with high avidity for ROS was required.
SPR analyses further confirmed these findings, demonstrating a high avidity for C1q binding to CS-A conjugated to the sensor chip.
Dengue serotype cross-reactive CTL clones showing high avidity for antigen produce higher levels of inflammatory cytokines than serotype-specific clones.
It is also possible that the frequency of the D1-1-specific CD8 T cells with high avidity for the epitope from bulk cultures may not be high enough, as shown in an analogous system by Stauss et al. [10].
T2 cells treated with WT1B-S1FA peptide, but not exposed directly to UV light demonstrated a small amount of MHC, (lane 3) consistent with its high avidity for the target.
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One possibility is that thymocytes expressing TCRs that have very high avidities for self-antigens actually are deleted due to the ectopic expression of peripheral "tissue-specific" proteins in the thymus [38], [39], [40], [41].
Furthermore, peptides TTM2 and MAP-M2 induced antibodies with highest affinity for the mimotope and highest avidity for measles virus.
Yet E5 demonstrates much higher avidity for peptide-MHC than C48 as demonstrated by staining with CD8-null tetramers (Figure 4).
HuA p321 had a higher avidity for Db MHC I compared to HuD p321, and HuD p321 bound Db with similar affinity to the control peptide NP.
In contrast to Ig fusion proteins, the ILZ fusion proteins show higher avidity for surface staining and do not bind to Fc receptors [32].
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