HOFFMAN: Kind of high analytic clock speed.
The habituation deficit in VEP has been demonstrated up to now only in pediatric photosensitive epilepsy (which may share some cortical abnormalities with migraine)[8] and in healthy subjects with a high analytic score[9], suggested to be increased in migraineurs[10].
We demonstrate a platform that integrates photonic crystal enhanced fluorescence (PCEF) detection of a surface-based microspot fluorescent assay with a microfluidic cartridge to achieve simultaneous goals of high analytic sensitivity (single digit pg/mL), high selectivity, low sample volume, and assay automation.
Testing methods for SNVs have high analytic validity and can reliably detect whether a SNV that was found to be associated with disease risk is present or not.
In our previous retrospective study for quality assessment, next generation sequencing (NGS) demonstrated a high analytic sensitivity and a broad reportable range for clinical detection of BRAF mutations.
We note that this study had a relatively high rate of BRAF mutation (42% of the follicular variants, as described above, and 60% of the tumors overall), which may be due to two factors: first, BRAF mutation may be more frequent in multifocal disease [ 18, 19] and second, our BRAF assay has high analytic sensitivity.
A genetic test may have very certain results and high analytic validity but the result may not be simple to interpret and therefore have unclear clinical validity or utility that will likely change over time as technologies and our clinical knowledge improve.
For self-sampling, use of a test with a high analytic sensitivity seems to be needed to ensure similar accuracy between clinician- and self-collected samples, probably because of the lower viral load in the vagina than the cervix (Belinson et al, 2010; Gravitt and Rositch, 2014; Zhang et al, 2014).
Higher analytic quality Hilbert pairs with sharper response can be obtained when there are more free-parameters.
Competitive learning atmospheres encourage students to develop higher analytic skills, while collaborative learning atmospheres prompt students to demonstrate higher synthetic skills.
