Accordingly, WCH16 (which is less virulent than WCH43 and D39) is predicted to have the highest amount of its domain activation in the lungs, with 74 predicted domains, compared to 31 for D39 and 23 for WCH43 (Table 2 and Additional file 12: Table S11).
Correlating these magnetic results with the structural characterization, one could understand the comparatively high coercivity of the Co nanowires as a direct consequence of the small grain size accompanied by the high amount of grain boundaries that hinder the domain wall movement.
Detailed examination of the distribution of amino acid variation across the sequenced domain regions shows functional constraint acting on specific regions of the enzyme coupled with an unexpectedly high amount of amino acid polymorphism concentrated in specific domain regions (Fig. 1, Table 5, Additional file 1 Figure S1).
It is similar to triglyceride-rich mobile lipid domains previously detected using 1H-NMR spectra of cell suspensions that detect mobile lipid domains that carry a high amount of triglycerides [11], [26], [28].
The data from the MinJ truncation experiments suggest that MinJ may be responsible for this, because a membrane associated MinJ-PDZ domain is able to promote cytokinesis, but is defective in disassembly as judged by the high amount of minicells.
Despite the high amount of observed and predicted α-helical secondary structure in hArc, hArc appears to be a flexible and modular protein, with loose 3D structure both within each domain and between domains.
The sociodemographic domain contains a mix of positive and negative features; therefore when the sociodemographic domain was constructed, positive variables were reverse-coded to ensure that a higher amount of the sociodemographic domain represented adverse environmental conditions.
