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Especially data sets having a high amount of background noise can gain from this process.
Secondly, it is well known that common DNA purification procedures are not highly efficient at recovering target DNA at low concentrations from a high amount of background DNA; which may also lead to an increase in the LOD [ 28].
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That LAMP is able to detect very small amounts of target and do that even in high amounts of background DNA makes it ideal for GMO detection.
Microarrays are sensitive to saturation effects and are also not able to detect transcripts that are expressed at a relatively low level due to high amounts of background fluorescence obscuring low hybridization signal to the probes.
However, when field samples, which tested negative in the nested PCR-EIA were spiked with the tenfold DNA dilutions, sensitivity decreased to 10-1 IFU, probably due to the higher amount of background DNA.
Interestingly, even in case of high amounts of benign background (up to 80% dilution), the classifier used by Chudova et al (2010) correctly recognised thyroid malignancy in the majority of their investigated FNA samples.
Recent research identified a high amount of zinc white with little Prussian blue, trace amounts of barium sulfate and small quantities of lead and possibly cobalt driers in the paint sample of the light blue background paint [32].
I use a very, very high amount of auto-tune.
It contains a high amount of fats.
However, a higher amount of clutter and background noise is reconstructed with increasing number of iterations.
Methods such as two-photon excitation or stimulated emission depletion (STED) geometry improve analysis by reducing nonspecific excitation of the background and photobleaching for systems with high amounts of autofluorescence or optical aberrations causing noncorrealated background signal that obscures traditional autocorrelation analysis.
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