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In contrast, the nicotine-exposed rats had the opposite progression with abnormally high alternation on days 22-30 abnormallyalow low alternation on days 35-52.
In the context of our study, we have interpreted high alternation rate as increased exploratory behavior in young and ACHE fish, and low alternation rate in aged animals as the development of stereotypy.
However, the behavioural strategy used by rats in some spontaneous alternation paradigms with very high alternation rates probably differs from the "standard" spontaneous alternation strategy.
Notably, however, animals can obtain a high alternation score in the continuous spontaneous alternation Y-maze task by adopting a consistent turn strategy (e.g. always turn left) which does not necessarily reflect their ability to remember which arms they have already visited.
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This increased competition could account for the higher alternation rates.
An increased number of different experimental conditions for the same genes will provide less genes in each set of coexpressed genes, more different sets, and higher alternation of the activation and deactivation of the coexpressed genes.
Finally, the local synchronization was measured at a low sampling rate, which impeded investigating high rhythm alternation in RE.
Similarly, RSV fed animals had significantly higher total alternation (22±5%) compared to CTL animals (U = 9, p = 0.025, Fig. 1B).
The pharmacological screening indicated in the Y maze test that all the drugs had significantly higher spontaneous alternation percentage than the nontreated LPS injected mice.
Normal mice have spontaneously high levels of alternation, whereas hippocampal-lesioned mice are dramatically impaired.
While it has been argued that the frontal cortex may be important when delays are introduced between the sample and choice trial (Seamans et al., 1995; Floresco et al., 1997; Taylor et al., 2003; Di Pietro et al., 2004), rodents with medial prefrontal cortex lesions can also show high levels of alternation at long delays (Gisquet-Verrier and Delatour, 2006).
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