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This overexpression of ICAM-1 molecules in cells treated with LPS for 5 h (shown in Figs. 6, 7) caused more binding between GNR/4MBA@Anti-ICAM-1 and ICAM-1 molecules on cell surfaces leading to high aggregation and finally resulting in the decreasing of the SERS signal.
Evaluation under polarized light showed both areas of high birefringence in the newly formed bone, indicative of the high aggregation and organization of collagen bundles of mature lamellar bone, as well as areas of low birefringence, indicative of the disorganized collagen bundles of immature bone.
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The lack of NO results in the development of endothelial disfunction, which in turn is a reason of higher tone of coronary vessels and higher aggregation and adhesion capability of thrombocytes.
Aβ4-42 aggregateshoweded a high aggregation propensity and stability.
However, some IUPs contain long repetitive sequence elements like Q/N-enriched stretches that have a high aggregation propensity and such stretches of the polypeptide chain can mediate the formation of beta-sheet aggregates (Altschuler et al., 1997 ; Chen et al., 2001 ; DePace et al., 1998 ).
This tool can be used to assign molecules to two different classes (Low and High aggregation risk), using sequence and structural descriptors as input.
We have recently shown that Aβ4 42 rapidly forms aggregates and possesses a high aggregation propensity [ 34].
Upon the addition of telomerase, AIE-MB induced comb-like DNA structure leads to high aggregation of silole-R and thus exhibits strong fluorescence emission.
Here, we found a correlation between high protein abundance and high aggregation propensity in vivo.
Otherwise, PEG-Lpx showed a Z-Average greater than 1 μm, high aggregation rate (PDI > 0.3) and a low E.E.
PASTA and AGGRESCAN further support an amyloid classification for SP-C, as both predict extremely high aggregation with relative PASTA energies and normalized hot spot areas of −29.2 (SP-C residues 8-28 as parallel β-sheet) and 128 (SP-C residues 12-35 as β-sheet) (Gordon et al., unpublished observations).
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