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These results, stemming from consensus and circulating HIV variants, support HIV's degree of similarity to host as a mechanism contributing to the intrinsic hierarchical profile of HIV-specific CD8+ T cell responses seen across different cohorts and host ethnicities [12], [44] [48].
The ordered hierarchical profile of the importance of different HDM allergens, found in subjects with a wide spectrum of allergic disease, provides a platform for the use of defined allergen formulations.
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The template alignment defines both the hierarchical relationships between profiles, the alignment of each profile to its parent profile within the hierarchy and, consequently, the alignment of each profile to the root profile, which, in our case, corresponds to the ELK structural core.
The procedure comprises the iterative derivation of sequence profiles followed by the hierarchical clustering of profiles.
In order to construct the hierarchical variable, 'occupational profile' multiple correspondence analysis (MCA) was used, followed by classification.
Many hierarchical clusters include profiles with strong pairwise correlations to profiles in other clusters.
When the profiles of altered expression of 54 miRNAs for the 6 organs were analysed by hierarchical clustering, the profiles appeared to be tissue specific.
Here we describe the unsupervised hierarchical clustering of profiling data from melanoma cell lines and melanocytes.
Based on normalized feature profiles, hierarchical and K-mean [ 17] clustering methods were used to cluster compound candidates.
MAPGAPS [ 63], a program to align sequences to a hierarchical set of profiles, was used to generate the final core domain alignment.
Based on the degree of similarity of metabolite abundance profiles, hierarchical clustering analysis was performed to show the global overview of all culture supernatant metabolites detected (Fig. 3).
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