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Through imposition of soft internal constraints (i.e., no lower/upper flux boundaries for upregulations/downregulations respectively) on a network by GX-FBA (see Methods), the behavior of a reaction can oppose hierarchical directives.
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The essence of Dr. Shefali's directive indicates parenting is not hierarchical, we are not "above" our children.
In industry more often there are hierarchical relationships, which may allow for more directive behavior.
To truly facilitate, and not be directive, is a difficult technique to learn, especially in a hierarchical society where the facilitator's education has emphasised rote learning rather than independence of thought [ 28].
Directives from the European Union, most notably the Clinical Trials Directive (2001/20/EC), add a further level to the structures for hierarchical accountability.
This paper presents the Land Suitability Index (LSI), a transparent, modular hierarchical system of cartographic indices aimed at delivering Strategic Environmental Assessment (SEA) of developmental land uses for regional planning (European Directive 2001/42/EC).
"It was very hierarchical.
Society is hierarchical.
"Most organizations are very hierarchical, and pay is hierarchical".
"It is a hierarchical society.
There was no hierarchical organization.
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