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With the exception of pregnant females, polar bears are active year-round, although they have a vestigial hibernation induction trigger in their blood.
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This elevation of pCO2 is thought to be an integral part of hibernation physiology as induction of an acidotic state serves to reduce metabolic rate and thermogenesis [ 25, 43, 44].
Hence, these parameters are critical elements for the induction of hibernation in Syrian hamsters under laboratory conditions [47].
Therapeutic induction of hibernation may remove this intrinsic protective mechanism with potentially deleterious results.
This is referred to as hibernation or hibernating myocardium.
Based on the concept that multiorgan failure secondary to shock, inflammation and sepsis may represent an adaptive hypometabolic reponse to preserve ATP homoeostasis, particular interest has focused on the induction of a hibernation-like suspended animation with H2S.
The regulated induction of a hypometabolic state resembling hibernation may protect the cells from dying once energy failure has developed, allowing the possibility of functional recovery.
The regulated induction of a hypometabolic state resembling hibernation may help the cell in facing a reduced capacity to generate energy.
Elevated expression of protein biosynthesis genes implies induction of translation in liver and heart during hibernation.
While hibernation is controlled by an internal annual rhythm [ 29], this induction of physiological changes can be overcome by some environmental factors.
Hibernating animals deposit enormous fat stores before entering hibernation.
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