STRs are very common in eukaryotic genomes, and are highly mutable, with changes in repeat count occurring with much higher mutation rates compared to other polymorphisms [as high as 2 × 10−3 in Y-chromosome STRs (Y-STR) as estimated by Heyer et al. (1997)], leading to allelic polymorphism.
"Hey, hey, FDA, how many people have you killed today?" chanted the crowd, estimated by protest organizers at between 1,100 and 1,500.
The material parameters appearing in the theory have been estimated for the metallic glass Pd40Ni40P20 from the experimental data of De Hey et al. [De Hey P, Sietsma J, Van Den Beukel A. Acta Mater 1998 46 5873].
When unequal population sizes were used as the null model, parameter values were estimated from the number of F, S, X1 and X2 sites [ 30] with J. Hey's Sites software (http://bio.cst.temple.edu/~hey/software/software.htm).htm
This could indicate insufficient information in the data to estimate migration and it is advisable in this situation to reduce the number of parameters (J Hey, personal communication).
To estimate the population demographic history in the divergence of riparian and inland species, we employed the IM model (Nielsen & Wakeley, [ 53]; Hey & Nielsen, [ 8]) using the program IMa (Hey & Nielsen, [ 54]).
To account for the difference in effective number of genes under X and autosomal linkage and its effects on levels of polymorphism, they also conducted coalescent simulations under IM-based (Hey and Nielsen 2004) estimates of demographic parameters.
Alternatively, positive values may also indicate a drop in population size, which is further supported by the method of Wakeley and Hey and insignificance of g estimates.
