Exact(2)
The orbitofrontal cortex (OFC) may be involved in the clinical and cognitive expressions of obsessive-compulsive disorder (OCD) and is a heterogenous region with respect to its cytoarchitecture, function and connectivity.
The resulting ∼650 bp amplicon (Figure 1Ci) containing this heterogenous region of HERV-W env gene was cloned, sequenced (≥11 cloned sequences per specimen) and aligned with established HERV-W env sequences.
Similar(58)
This results in aberrations rapidly increasing with depth around the heterogenous regions.
The loss of significant correlations at larger scales is likely due to smaller sample sizes and thus less statistical power, and typically, a reduction in magnitude at large scales is likely due to averaging across heterogenous regions contained in the larger windows.
We therefore speculate, that since the neocortex is a very heterogenous brain region, observations concerning a disturbed plasticity might be hard to detect when the entire cortex is analyzed.
The second possible reason is that the larger windows average across heterogenous genome regions; this certainly appears to contribute to the differences given that even at 100-kb resolution, the correlation between recombination and gene density differs among chromosome arms (positive correlations on some arms and negative on others).
A spatially heterogenous distribution of regions with enhanced permeability was also observed.
For other genomic aberrations in ccRCC, the literature is heterogenous with different regions implicated for survival in different cohorts.
In contrast, Platzer et al. found that underexpression was more common than overexpression in amplified regions[ 20], and a study by Staub et al. found that deleted regions usually show underexpression while amplified regions exhibit heterogenous expression.
GC content and sequence identity of ITS regions within heterogenous accessions was calculated using BioEdit (http://www.mbio.ncsu.edu/BioEdit/bioedit.html).html
There was no significant difference in survival between geographical health regions for this heterogenous group of 127 patients: 78% 5-year survival (low-volume regions) vs 66% 5-year survival (high-volume region) (p = 0.31).
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