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Accumulating experimental evidence also suggested that stem cells are heterogeneous, with cells moving between two or more metastable states [ 33].
In agreement with previous reports [ 44], early passage cultures were heterogeneous with cells displaying spindle-shaped, flat, and fibroblast-like morphologies).
Although the analysis of the data is consistent with neutral competition between 13 equipotent CySCs, by the nature of the neutral competition model, we cannot rule out the possibility that the stem cell compartment is heterogeneous with cells moving reversibly between states in which they become primed for duplication or loss, as recently defined in the mouse intestinal crypt (Ritsma et al, 2014).
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These tumours are clinically and biologically heterogeneous, with cell populations differing in their genetic programs, maturation stage and malignant potential [ 2].
Interestingly, PTEN-deficient/ErbB-2KI mammary tumors were heterogeneous, with some cells having characteristics of basal cells such as SMA expression.
Signals from parasitized CB RBCs, however, were heterogeneous, with some cells showing AA-like patterns (Fig. 3b) and others showing dim and uneven patterns (Fig. 3c) reminiscent of HbC and HbS RBCs [10], [11].
Moreover, the pattern of expression was heterogeneous, with some cells expressing more protein than others.
As we described in Fig 1B, the response to suboptimal NE concentrations is heterogeneous with some cells not depolarizing.
At these early time points, staining was heterogeneous, with some cells stained in a ring pattern, but most being partially capped.
These cells were heterogeneous with respect to cell surface markers and were separated by flow cytometry into CD44 and CD24 positive and negative subgroups.
Morphological analysis revealed a heterogeneous cell population, with cells displaying a fibroblast-like, epithelial-like and also neuron-like features.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com