While pools of HIV-1 particles are highly heterogeneous, studies of HIV nuclear entry are typically limited to population-averaged information.
Dr. Stampfer and others say its analysis is methodologically flawed, because it includes data from widely heterogeneous studies, excludes data from hundreds of others for unclear reasons and does not try to detail the causes of increased mortality among supplement users.
Caution should be exercised because the available evidence largely originates from heterogeneous studies with weak designs, conducted in experimental settings with nonclinical participants (i.e., medical students).
Although obtained from heterogeneous studies, the detected changes might be the result of the different pathophysiological substrates underlying OSAS, RLS, insomnia and sleep deprivation rather than reflect the general effect of non-specific sleep loss and instability.
Given that these estimates come from averaging heterogeneous studies, we should exercise some caution in interpreting the rank order of the Gini coefficients.
The mean global estimate is based on a large number of heterogeneous studies, performed with varying methods during a period of >30 years.
Although the authors employed specific inclusion and exclusion criteria, they maintained this conclusion may be difficult to interpret given that the meta-analysis was based upon small, non-blinded, heterogeneous studies at a high risk of bias.
This study is aimed at quantifying the prospective association between measured physical activity and fat mass in children, using a meta-analysis method that allows inclusion of heterogeneous studies by adjusting for differences through eliciting and incorporating expert opinion.
Sensitivity analysis identified heterogeneous studies that influenced the meta-analysis.
This process allowed for comparison across the heterogeneous studies.
However, this conclusion is based on heterogeneous studies of variable quality and only two randomised trials.
