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How such heterogeneous sequence composition relates to function and could give rise to a transport mechanism is still unclear.
This might result from methodological bias in detecting SNPs from a very high coverage and heterogeneous sequence data.
Comparison of insert positions and sequence conservation within the C-terminal linker region demonstrated that mutants harbouring inserts at positions of overall conservation showed loss of transport activity, whereas insertion into heterogeneous sequence parts was, in general, compatible with autotransport activity (Fig. 5B).
The hcpA marker showed heterogeneous sequence chromatograms for both forward and reverse primer sequences.
Another hurdle to de novo assembly is recovering rare transcripts from a datasets with heterogeneous sequence coverage.
This is attributable to the heterogeneous sequence organization of PREs and low conservation of consensus sequences for the binding sites of PRE-binding proteins.
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None of the predicted SVs were found by IMR/DENOM because of the heterogeneity of the sample, highlighting the advantage of using SHEAR on heterogeneous sequencing samples.> -wrap-foot> Left and right breakpoint locations on the reference sequence are given for each predicted structural variation, as well as the estimated levels of heterogeneity.
We compare our results with IMR/DENOM [ 11] to demonstrate the advantages of our approach, namely, improved computational efficiency, better support for tandem duplications, and the ability to handle personal genome assembly in the presence of heterogeneous sequencing samples as well as to estimate the level of that heterogeneity.
An approach to solve similarity problems could be the transformation of these heterogeneous sequences into uncertain temporal relations, obtaining a temporal constraint network.
Furthermore, temporal similarity measures cannot directly apply the efficient time series techniques, requiring new approaches to deal with these heterogeneous sequences.
These proteins also have the flexibility to bind heterogeneous sequences, such as the so-called TAATGARAT motif [22].
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