Sentence examples for heterogeneous phenotype of from inspiring English sources

The NLRP3/CIAS1 E311K mutation caused a heterogeneous phenotype of MWS in a large family.

From these studies, it is becoming clear that SCLC exhibits a heterogeneous phenotype, of which further investigations are warranted.

However, the complex etiological pathways from polygenetic origin to gene-environment interactions to the heterogeneous phenotype of ADHD are still not well understood [ 6].

These findings were consistent with what was observed during the proteomic analysis and may reflect the more heterogeneous phenotype of AML and MM patient populations, compared with the CLL patient population.

Given the heterogeneous phenotype of gastric cancer, the present study primarily aimed to compare copy number changes between intestinal-type adenomas and pyloric gland adenomas, in order to find leads towards genetic pathways involved in the pathogenesis of gastric cancer.

While blastemal cells appear as a homogeneous population, we further analysed cell fractions within the NCAM+ population and discovered that 200 purified NCAM+ALDH1+ cells were able to initiate WT xenografts, recapitulate the heterogeneous phenotype of their parental WT and further propagate in mice, reflecting both the differentiation and self-renewal capacities of CSCs (Li et al, 2007).

Moreover, because of the theoretical presence of undiscovered biomarkers in the total proteome, pattern recognition algorithms or machine-learning methods could be applied to link SWATH maps with the heterogeneous phenotypes of the samples.

With increasing recognition of the heterogeneous phenotypes of NET and expanding multimodality treatment options, we believe that a more individualized approach should be adopted to further maximize therapeutic benefit.

Additionally, cancers derived from purified CIC/CSCs recapitulate the heterogeneous phenotypes of the parental cancer from which they were derived, reflecting the differentiation capacity of CSCs (Reya et al, 2001; Singh et al, 2004).

Importantly, these cells are total populations of AI-resistant cells and may thus also mimic the heterogeneous phenotype and behavior of resistant cells possibly present in the tumors of patients who relapse under AI endocrine therapy.

In the mouse mammary gland, tumors resulting from disruption of the Wnt pathway (Wnt tumors) exhibit complex and heterogeneous phenotypes comprised of intermingled epithelial and mesenchymal derivatives.