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This heterogeneous origin of miRNAs suggests each group of miRNAs with the same origin may be generated and maintained in a different transcriptional pathway.
Despite the heterogeneous origin of the blastema cells, histologically they appear as a homogeneous population of cells and therefore have been traditionally viewed as a single cell type.
Thus, the global miRNA expression profiling may represent the most appropriate technology for monitoring the progression of liver damage and exploring the heterogeneous origin of HCC.
Yet to be resolved is the potentially heterogeneous origin of neural progenitors (NPs) in the hippocampus and whether they exhibit different abilities to respond to disease or injury during the lifespan of the organism.
Cumulative studies from the zebrafish, chick, mouse and human models have revealed a heterogeneous origin of the endothelial lineages in the heart, and have recently indicated that a subset of these ECs are derived from a distinct origin of multipotent heart progenitors located in various specific regions of the early heart field.
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The polyphyletic pattern suggested the possibility of heterogeneous origins of this species complex.
The idea that virtually all human melanomas and hepatocellular carcinomas have a similar phenotypic defect with regard to argininosuccinate synthetase is inconsistent with the heterogeneous origins of tumours.
Unfortunately, earlier studies focused on the ontogeny of peptidergic neurons in the rodent hypothalamus (e.g., those reviewed by Markakis 2002) did not take into account at all the possibility of tangential migrations, giving the impression of highly heterogeneous origins of multiple cell types.
This fact could be regarded as a reflect of a possibly heterogeneous origin for the extra-pelvic recurrence or either as an artifact of the hierarchical clustering process, which does not take into account the CNVs observed in this tumor.
Here we report on a meta-analysis approach that integrates data of heterogeneous origin in the domain of type-2 diabetes mellitus (T2DM).
The mosaic is baffling in its complexity: the cultures have interpenetrated one another as a result of constant migratory movements and through intertribal relations, leading to the obliteration of formerly significant differences, and to new cultural systems made up of elements of heterogeneous origin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com