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To convince the readers that there is actually significant shortening of telomeres, with these heterogeneous lengths, it would be necessary to show several independent clones and show a decrease occurs reproducibly in several independent clones.
This was confirmed by SDS PAGE, which shows a smear for these samples [caused by the incorporation of heterogeneous lengths of peptidoglycan polymers (see the inset in Figure 6B and Figure 7 of the Supporting Information)].
Type I survivors amplify subtelomeric Y´ elements and have short terminal telomeric repeat tracts, whereas Type II survivors amplify telomeric sequence from the very end of another telomere, resulting in highly heterogeneous lengths of terminal telomeric repeat tracts (Lundblad and Blackburn 1993; Teng and Zakian 1999).
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Next, we created a sample of heterogeneous length by mixing equal quantities of labeled 10 and 25 base-pair duplexes.
In contrast, miRNAs have a more heterogeneous length ranging from 20 to 24-nt.
Because of heterogeneous length of sequences, different subsets of sequences were used to estimate the age of all nodes (see additional file 1b).
It has been shown that Lin28 promotes generation of uridylated pre-let-7 with heterogeneous length of uridine (U -tail in cells expressing Lin28A or Lin28B.
One proband, with the typical clinical presentation of bipolar disorder, carried an expanded C9ORF72 allele of heterogeneous length between 14 and 20 kilobases (kb) as assessed by Southern blot.
Since the long fragment could not be obtained in all museum specimens, we had to work with haplotypes of heterogeneous length (31 were detected overall, see Additional file 1a).
An expression for R* has been found in the case of metapopulation epidemic models with different types of mobility processes, including homogeneous, traffic-driven, and population-driven diffusion rates [ 28, 46], commuting-like processes [ 47, 48] and origin destination processes with adaptive behavior [ 49] or heterogeneous length of stay at destination [ 50].
The revised pipeline (called Celera Assembler with the Best Overlap Graph, CABOG) was robust to uncertainty in homopolymer run length, high read coverage and heterogeneous read lengths.
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