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These results suggest that highly expressed B-cell-specific and, potentially, monocyte-specific differentially expressed genes can be detected from heterogeneous gene expression in SLE population.
These observations illustrate a wide dynamic range of average expression and variability of both raw counts and FPKM measures in the heterogeneous gene expression data, suggesting potential difficulties in detecting differentially expressed genes.
However, due to random integration of lentiviral-delivered genes in the host cell genome, nonuniform, i.e. heterogeneous, gene expression within the host cell population is expected.
Heterogeneous gene expression is one of the unique properties of ESCs (Niwa et al., 2009).
We found that T cell activity enhances most genetic and functional stem-like properties within gliomas, but fails to unconditionally enhance either tumorigenicity or heterogeneous gene expression, thereby providing further clarification on the role of stem-like tumors in glioma malignancy and diversity.
To further clarify the potential impact of anti-tumor T cell activity on glioma genetic heterogeneity, and to formally address whether the lack of anti-tumor T cell activity can enhance heterogeneous gene expression in glioma, we assessed microarray profile similarity among biological replicates of GL26nu, GL26B6, and GL26B6V (all dervived from the same parental tumor).
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Analytical techniques can also be used to help distinguish biologically meaningful heterogeneous gene-expression differences from those arising from technical noise.
Anti-tumor activity of SN35539, the phosphate pre-prodrug of SN34507, was established in 'mixed' tumors harboring a minority of NfsA-positive cells and demonstrated marked tumor control following heterogeneous suicide gene expression.
BEST, a computer program implements this algorithm, is able to query large and heterogeneous microarray gene expression databases for regulon discovery.
When this pathway is active, however, the stem cells become heterogeneous in gene expression even though differentiation can largely be prevented by LIF.
Because DLBCL is a group of highly heterogeneous diseases, gene expression profiles would be popularized and used directly to guide treatment.
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