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Molecular targeted drugs sometimes show heterogeneous efficacy among lesions in different organs.
Therefore, our model is complementary to other models, such as the s.c. model and transgenic mouse model, in that it will allow researchers to evaluate the heterogeneous efficacy of ALK-TKIs on multiple organ lesions and contribute to the development of novel therapies for EML4-ALK lung cancer.
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In view of this, the discrepancies in the TAA profiles should be a critical reason for heterogeneous therapeutic efficacy.
This artificial separation FGA/SGA is not consensual due to their heterogeneous profiles of efficacy and tolerability (especially for SGA) [ 17, 18].
A number of intervention trials have been published and show heterogeneous results in efficacy in reducing excess gestational weight gain [ 32, 33].
In CER, co-interventions (e.g. pain medications in pain trials) are often more heterogeneous than in efficacy trials, and for understanding the context of the study, it is relevant to document and report them.
The clinical implications of ITH and strategies to improve treatment efficacy in heterogeneous cancers will be discussed, highlighting the potential role of epigenetic therapeutic interventions.
Mindfulness-based interventions (MFIs) have been integrated into therapeutic work on depression, but limited systematic reviews reported their efficacy on heterogeneous groups of mental disorders.
However, a direct comparison of the efficacy of heterogeneous stem cells and their clonal progenies has yet to be made.
The suboptimal efficacy of heterogeneous stem cells in muscle regeneration has prompted recent interest in exploring single cell clones.
Published data are heterogeneous in terms of efficacy in the different histotypes.
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