Limited, heterogeneous effectiveness data required narrative synthesis, illustrated by plotting sensitivity and specificity in receiver operating curve (ROC) space.
In the present study, we further demonstrated the expression and clinical value of multiple antigens on a protein level, which should be the critical reason for heterogeneous effectiveness of immunotherapy and provide supportive evidence for 'immunoediting' in human cancers.
The reconstruction of immune surveillance for aberrant cells requires adequate tumour-associated antigen (TAA) expression, and the distinct expression pattern of TAAs in different tumours may be a critical reason for heterogeneous therapeutic effectiveness.
The second key factor for virulence evolution in heterogeneous host systems, effectiveness of between-host transmission (Gandon 2004; Osnas and Dobson 2011; Williams 2012), was made to vary in simulations of the model within ranges compatible with apparent infection rates of CMV disease progress curves (Alonso-Prados et al. 2003).
The existence and effectiveness of heterogeneous genome constellations remains unclear, probably because it is caused by mechanisms that create protein sets that work better when kept together (8 ).
Both reviews found that patterns of intervention design and results of effectiveness were heterogeneous, therefore it was difficult to generalize the effectiveness of particular interventions for particular patient/client groups.
The panel recommended that targeting a heterogeneous population for an effectiveness trial could be helpful, since it would allow researchers to test the robustness of the effects across different types of patients, and might allow a subgroup analysis to be performed.
Alerting protocols are highly heterogeneous and evidence on effectiveness is mixed; they have been shown to improve preventive care [ 50], but multiple studies have also found high rates of overriding alerts and reminders in physician order entry and decision support systems [ 29].
Such activities are often characterised by high coverage in selected parts of the population which are screened too frequently, coexisting with a low coverage in other population groups with less socioeconomic status, and heterogeneous quality, resulting in limited effectiveness and poor cost-effectiveness.
In general, diffusion limitations within the heterogeneous phase can lead to effectiveness factors much greater than unity for both exothermic and endothermic autocatalytic reactions.
Increasing the initial content of ZnO diluent increases the effectiveness of the heterogeneous reaction at the ZnO diluent surface which facilitates the sublimation of Zn and appears to render the ZnO product scale surrounding unreacted Zn more permeable.
