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The heterogeneous basis of the analysis crystallises out the specific differences between the medical disciplines.
We present two different models of 0/1 variables, one that is possible under a homogeneous basis change, and one that is possible under a heterogeneous basis change only.
Analysis using mathematical modelling suggests the heterogeneous basis for the inheritance of bipolar disorders [ 36].
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The majority of the encoded proteins have been identified as components of the pathological inclusions, emphasizing the heterogeneous molecular basis of both FTLD and ALS.
Consistent with the observation that the heterogeneous molecular basis of JATD has not been fully determined yet, we have identified two consanguineous Saudi families segregating JATD who share a single identical ancestral homozygous haplotype among the affected members.
Exploiting new sequencing technologies, a "gene panel" approach can be implemented in the diagnosis of conditions that share clinical signs but have a heterogeneous molecular basis (e.g., lysosomal storage diseases with skeletal involvement or osteogenesis imperfecta and bone fragility disorders, known to be associated with more than 10 different genes) [1].
It is a very largely heterogeneous disease but basis for its phenotypic and genomic multiplicity remains uncertain, though continued proteomic and sequence-level analysis of its architecture is likely to provide insight.
The genetic advances of the past two decades have transformed our understanding of human diseases and with the greater availability of next-generation sequencing technology, it has become apparent that most eponymous syndromes have a heterogeneous molecular genetic basis and should be viewed as largely historical descriptions.
When significant heterogeneity and inconsistency were found, the most heterogeneous study on the basis of the forest plot was removed and the analysis was redone [ 20].
Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood.
In particular, this prototype vehicle allowed the experimental validation of algorithms and methodologies proposed and developed by different research groups cooperating on the basis of heterogeneous programs.
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