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The connection to FOXO6 would be strengthened if it were shown that FOXO6 function was heterogeneous and matched SOX2 expression.
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In this experiment, we used a more complex, heterogeneous background and matching target to try to replicate the previous findings.
In healthy volunteers under mechanical ventilation, Nyrén and colleagues [ 5] showed that regional lung perfusion and ventilation were heterogeneous, but matched each other, which was essential to optimize gas exchange.
Autoradiographic studies confirmed higher 99mTc-B-collagelin uptake on sections of lung of mice with pulmonary fibrosis as compared to controls with heterogeneous distribution matched with that of picrosirius staining (fig 6C).
In cases where the environment is heterogeneous and different genotypes match different patches in the environment, FAD can result in better genotype-to-environment matching [ 49, 75] and accelerate local adaptation [ 59, 76].
To check whether there are heterogeneous effects and to improve matching quality, we estimate LPMs and matching models for different subsamples (Table 4).
A principle conceptual difference between regular regression estimations and matching estimation is that the latter gives the researcher greater flexibility in choosing how to aggregate heterogeneous effects, especially when using the specific technique coarsened exact matching.
To assess its potentials, experiments with well-known learning algorithms and classification datasets are discussed whereby the accuracy, generalization and diversity levels achieved with heterogeneous Bagging are matched against those delivered by standard Bagging with homogeneous components.
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