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Even though our analysis did not detect statistically significant heterogeneity, study samples are heterogeneous according to mean initial weight, length of illness, diagnosis, and pharmacological therapy.
The drug heterogeneity study showed that burst release (i.e. dose-dumping) increased as drug loading increased since the polymer could not form a gel layer to surround the tablet but the time taken for 99% drug release was not significantly different when compared to the homogeneous case.
After obtaining the temperature, the heterogeneity study can be conducted with the random matrix for porosity and permeability distribution through special random functions.
The heterogeneity study together with the above TG-DTG analysis (Sect. 3.1, Fig. 1d) identified that the catalyst had good solvent and thermal stability, resulting in the excellent recycling performance under the studied reaction conditions.
However, the heterogeneity study showed a significant difference among these studies.
48 Likely reasons contributing to the discrepancies among studies include disease heterogeneity, study design, and power limitations.
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Within the European Union the forms of heterogeneity studied here are increasingly evident at the landscape scale.
In order to reduce the influence of heterogeneity, studies between different subgroups are required.
Finally, the throughput of single-molecule sequencing is too low for heterogeneity studies.
Meta-analysis has some limitations: notably publication bias of included studies and heterogeneity of study designs[33].
Factors accounting for the heterogeneity between studies warrant further study.
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