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Further analysis was therefore required to minimise the number of markers needed to classify patients into these distinct breast cancer classes but retain the sophistication of the classification, maintain the clinical heterogeneity of classes, and reduce the unclassified tumours to a lower level while retaining usefulness for clinical decision making.
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The use of H score allowed the heterogeneity of HLA class I expression to be taken into account.
In order to characterise the heterogeneity of the two classes of disorders, we computed neuroanatomical variability within each class and between classes.
The other limitation of the review was the heterogeneity of study designs, class of bacteria, and drug classes investigated, which makes comparing study findings problematic and makes it inappropriate to conduct a meta-analysis for all studies.
On the other hand, it is possible to classify samples into the Gaussian subcomponents inferred for each phenotype class, a variation of MDA called Heterogeneous Mixture Discriminant Analysis (MDAhet), because this explicitly takes the heterogeneity of each phenotype class into account by attempting to classify the samples into these subcomponents.
In the present analysis, the heritability estimate for DPs due to mental disorders was 42%, which is probably due to the etiological heterogeneity of the broad class of mental disorders as well as due to specific factors leading to disability pension among those with a diagnosis.
We argue that an important factor to be put into perspective regarding this issue is the heterogeneity of the professional class, especially of psychiatrists [ 31].
A further issue is the heterogeneity of the HLA class II distribution and the variation of smoking frequency between the European populations, which will have affected the consistency of the results.
Quantitative analyses showed that Ceacam10 is expressed in 71.2% ± 6.3% of C-LTMRs, Wfdc2 in 73.4% ± 1.7%, Cacna1i in 89.2% ± 5.9%, C1ql4 in 70% ± 1.8%, Fbp2 in 19.9% ± 4.7%, and Bok in 62.7% ± 6.4% of C-LTMRs, further highlighting our previously suggested molecular heterogeneity of this particular class of neurons (Delfini et al., 2013).
Heterogeneity of variances among effect classes allows individuals that are in more variable classes to have a greater impact on resulting EBV.
Heterogeneity of some of the classes and the residual noise (variance within class) which remain even after discarding the fourth and the subsequent PCs: as mentioned previously, variance within class in real-life datasets, unlike the variance within class in toy datasets (which is fixed at 1), differs from class to class even within the same dataset.
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