So in either case, the claim that controlling for spatial heterogeneity establishes that minimum wages do not reduce employment of unskilled workers is unfounded.2.2
Uncorrectable heterogeneity, established publication bias, residual confounding variables, and healthy-user bias have always been deep concerns of investigators.
Retroviral overexpression of just two oncogenes in HSCs from inbred laboratory mice cannot model the physiological cell state of transformed human HSCs, nor the molecular and functional heterogeneity established during the human disease.
The high level of heterogeneity established in our study, compared to other studies, may be due to the different culture media that were used and to the use of separate swabs for sampling vagina and rectum for each individual woman.
Third, in so doing, a more nuanced understanding of the processes that give rise to a pathological state can help refine the nosology of disease, clarifying its heterogeneity and establishing particular subtypes.
Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic gene alterations (MYC) had not been systematically studied.
The advance of Moore's law and the increasing complexity and heterogeneity of established and leading edge processes along with increasing robustness and dependability requirements further kindle the interest in efficient analog electronics design automation.
Furthermore, it is possible that tumors arise at a later time point, since primary ovarian cancer cells from patient biopsies display much greater heterogeneity than established cancer cell lines.
Tremendous efforts have been made in the last 15 years to determine how interneuron heterogeneity becomes established (recently reviewed in [ 4,5,6,7,8]).
Thus, there is substantial evidence not only for intralaboratory cell line heterogeneity within established cell lines, but also for drift away from the phenotype of the originating tumour.
