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Heroin tolerance will be reduced, so the risk of fatal overdose will be much higher".
"Hair analysis," says Baumgartner, shows that "people don't realize the dangers of lowered heroin tolerance".
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Dr. Herbert D. Kleber, the medical director of the National Center on Addiction and Substance Abuse at Columbia University, estimated that at least half the sniffers wound up injecting their heroin as tolerance developed for the drug.
In a context of 315,000 heroin addicts, the tolerance limits for experiments seeking "fundamental answers to the mysteries of drug effects" are bound to be extended.
"However, tolerance to heroin and other opiate drugs appears to be lost fairly rapidly when users cease to use the drug, and deaths commonly occur in people who have previously been tolerant and have returned to using heroin".
People who use heroin regularly develop a tolerance for it (they require larger doses to get the same effects).
Blue heroin may not cause tolerance to occur as reliably as in a person who has only previously used white, for example.
The transition from prison back into the community is particularly hazardous for drug-using offenders whose tolerance for heroin has been reduced by imprisonment.
As their tolerance increased, these new heroin snorters overcame their aversion to needles and soon turned into heroin injectors.
Dangerously, he had misjudged his tolerance after years without heroin.
Peaches had been taking strong levels of heroin, he said, but that her tolerance levels had declined over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com