Hypertriglyceridemia (HTG) is a heritable risk factor for cardiovascular disease.
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and cardiovascular diseases.
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease.
Despite these successes there remains a substantial portion of the heritable risk of PE unaccounted for.
High-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride concentrations are heritable risk factors for vascular disease, but their role in the progression of chronic kidney disease (CKD) is unclear.
Identification of genomic loci containing these heritable risk factors has been slowed by the rarity and late onset of PBC, which has made difficult the collection of sufficient numbers of patients and family members for meaningful genetic analyses.
It is clear that next-generation technologies will be used in study designs similar to GWAS to identify additional heritable risk factors for CNCDs.
The GCI can be populated with heritable risk information of any type, and thus represents a framework for CNCD pre-symptomatic risk assessment that can be populated as additional risk information is identified through next-generation technologies.
Familial aggregation of high IFNα serum levels as well as the presence of the IFNα signature among SLE patients and families suggests heritable risk factors related to IFNα[53].
