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DNA hypermethylation is an epigenetic and heritable modification.
In Aspergillus, low concentrations of 5-AC are known to increase the formation of "fluffy" phenotypic variants [47], [58], an effect postulated to occur through the heritable modification of a single nuclear gene, fluffy-F1 (FluF1) [58].
Epigenetics is the heritable modification of gene expression without changes in the DNA sequence.
Heritable modification of chromatin or DNA leading to fixation of gene expression programs is a key component in demarcating potential during development.
One might say that methylation is a stable and heritable modification, but at the same time, it may be affected by the environment.
DNA methylation is the only known heritable modification of DNA, and is aberrant in cancer, involving both excessive and insufficient methylation of DNA regions of cytosine guanine bonds (CpG), which then alters the expression of certain genes [ 2].
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Such epigenetic signatures encompass the heritable modifications that do not change the DNA sequence but rather provide 'extra' layers of control that regulate chromatin organization and gene expression [30], [31].
Epigenetic changes are heritable modifications affecting gene expression without causing alterations in the nucleotide sequence itself [ 13].
Epigenetics is defined as the study of heritable modifications to gene function that occur without alterations in DNA sequences.
Epigenetic mechanisms are stable and heritable modifications responsible for regulating gene transcription without altering the DNA's nucleotide sequence [ 1].
Epigenetics can be defined as the study of mitotically or meiotically heritable modifications in the function of specific genes not related to modification in the DNA sequence [ 24].
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