Sentence examples for heritable loss from inspiring English sources

As knockout results in a permanent and heritable loss of EZH2, expression cannot be recovered post knockout.

A transgene can be epigenetically silenced by a process called RNA directed DNA methylation (RdDM), which can be seen as a heritable loss of gene expression.

The SB method uses cut-and-paste transposable elements to generate heritable loss-of-function mutations.

This is currently the method of choice for obtaining heritable loss-of-function mutations in C. elegans but there are also drawbacks to this approach.

Therefore efforts have focused on the development of methods for targeted gene knockdown in zebrafish [46 48], with the recent reports of zinc finger nuclease (ZFN) technology holding promise for the widescale and specific generation of heritable loss-of-function alleles [49 51].

We and others have shown that the SB transposon is highly active in the mouse germline and can generate heritable loss-of-function mutations that lead to detectable phenotypes [ 4- 7].

Retinitis pigmentosa is one of the most common forms of the 250 known types of heritable vision loss, and is characterized by progressively diminishing sight due to the death of cells within the retina.

We have adapted TALENs to engineer heritable, predicted loss-of-function mutations in three endogenous genes of the marine annelid P. dumerilii.

As such heritable or acquired loss of p62 may cause accumulation of cellular oxidative injury due to dysregulation of Nrf2 activity.

Consistent with development of homozygosis for epigenetically repressed loci, a significant proportion of cells with a defective CRABP2-mediated RA transport developed heritable phenotypes indicative of loss of function.

The hair loss is heritable, androgen-dependent, and occurs in a defined pattern.