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It is likely that, given the same type and degree of insult, there are heritable determinants of susceptibility to ARDS.
In order to identify heritable determinants of longevity we set up the Leiden Longevity Study.
Twins have also been used to suggest the existence of heritable determinants of epigenetic change.
It has been assumed that heritable determinants contribute significantly to both BPD [ 8, 23] and RDS [ 24].
Therefore the cases of disease among MZ twins can be presumed genetically representative of the population, and disease-concordant pairs must necessarily share all heritable determinants.
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The identification of heritable genetic determinants of metastatic potential could have profound effects on cancer treatments by improving cancer treatment decisions.
Although HDL-C levels are highly heritable (h2∼0.7), the genetic determinants identified through GWAS contribute to a small fraction of the variance in this trait.
Thus alleles such as those at CYP 17 (Henderson and Feigelson, 2000) are unlikely to be the predominant determinants of heritable disease.
It becomes increasingly clear that genetic information encoded in the primary DNA sequence is not the only determinant of heritable phenotypes.
This is in line with the growing consensus which suggests that although heritable morphological traits are determined by the expression of structural genes, it is the regulatory genes which are the prime determinants of allelic identity.
This reproductive strategy has strong environmental determinants but is also partially heritable (Prevost et al. 1992; Aubin-Horth and Dodson 2004; Piche et al. 2008; Paez et al. 2011; Dodson et al. 2013) and might have been by maintained through negative frequency-dependent selection (Hutchings and Myers 1994; Aubin-Horth et al. 2005).
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