Overall, although there are no studies that have quantified the heritability of transcription profile differences underlying ecological speciation, these results suggest that the heritable component of gene expression exists, but is highly variable.
Future studies should focus on the estimation of the heritability in protein expression profiles.
These results compare to other median heritability estimates among genes with heritable transcription profiles ranging from 0.11 (in mice, Ref. 111) to 0.84 (in yeast, Ref. 112).
Based on the high heritability estimate of DNA methylation profiles of multiple CpG sites, we performed association mapping using DNA methylation levels as quantitative traits.
We inferred sampling at flowering would increase heritability by allowing unique exudation profiles to affect rhizosphere microbiota before transition of carbon flow.
Familial aggregation and heritability analyses of arsenic metabolic profiles suggest that genetic factors influence interindividual variation in arsenic methylation capacity (Chung et al. 2002; Tellez-Plaza et al. 2013).
In different studies as well, HDL-C, obesity and lipid profiles showed the strongest heritability, and BP and FPG had the lowest heritability.
Baydas, B., Erdem, A., Yavuz, I. & Ceylan, I. Heritability of facial proportions and soft-tissue profile characteristics in turkish anatolian siblings.
These developments are geared toward explaining a part of the missing heritability, and when combined with individual genomic profiling, such systems medicine approaches may also provide a principled means for tailoring personalized treatment strategies in the future.
Since cancer is characterized by a peculiar gene expression profile, another mechanism that could explain "missed heritability" is posttranscriptional regulation.
Figure 4 illustrates the LR profiles for the data simulated under different heritability levels and sample sizes.
