Sentence examples for hereditary pathways from inspiring English sources

As new candidate genes are discovered and hereditary pathways identified using technologies such as genome-wide analysis, the possibility of prevention and treatment becomes more tangible for millions of women affected by endometriosis.

This can be represented schematically as: The distinction between genotype and phenotype was introduced by Wilhelm Johannsen in 1908 as a consequence of the realization that the hereditary and developmental pathways were causally separate.

Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown.

In hereditary cancers, an alternative pathway involving MSI is thought to play a role.

These data are interesting given that TGFβ signaling is necessary for angiogenesis and mutations in genes encoding proteins involved in this pathway cause hereditary hemorrhagic telangiectasia in which defects in angiogenesis predispose to ICH.

It is generally assumed that sporadic and hereditary cancer sharing common inactivated pathways may be biologically similar, although discussion is ongoing.

The study of genetic discriminators and deregulated pathways involved in hereditary ovarian syndromes is relevant for the future development of molecular diagnostic strategies and targeted therapeutic approaches.

It was suggested that MSI-H sporadic and hereditary tumors follow parallel evolutionary pathways during tumorigenesis in terms of both genotype and phenotype [ 23].

This knowledge sets a firm basis to dissect the underlying disease mechanisms further, to elucidate common and divergent pathways leading to hereditary neuropathies, and eventually to provide hints as to novel molecularly targeted treatment strategies.

In 1996, inactivation of this pathway was linked to the hereditary developmental disorder holoprosencephaly, whereas hyperactivation of this pathway was linked to human cancer [7]– [7]].

Cancer-related pathways (pancreatic adenocarcinoma signaling, hereditary breast cancer signaling, and role of BRCA1 in DNA damage response) were also highly enriched in the gene list.