Sentence examples for hereditary mutations from inspiring English sources

Some people carrying hereditary mutations in RET will develop medullary thyroid carcinoma at a young age.

Some prion diseases are caused by hereditary mutations in the gene encoding this protein.

During the late 1950s and early '60s Arber and several others extended the work of an earlier Nobel laureate, Salvador Luria, who had observed that bacteriophages (viruses that infect bacteria) not only induce hereditary mutations in their bacterial hosts but at the same time undergo hereditary mutations themselves.

Nearly all patients affected by medullary thyroid carcinoma or MEN2 have hereditary mutations in the RET (rearranged during transfection) proto-oncogene (a gene that can become a cancer-causing gene, or oncogene).

As follows from this review, neither the reliable spectrum of mtDNA somatic mutations nor the association between hereditary mutations and colorectal cancer risk have been resolved.

Some of these changes have been characterized to provide a clear contribution to the development and/or progression of the cancer and include overexpression of HER2/neu in about 20% of breast cancer [1], and hereditary mutations in BRCA1 or BRCA2 in approximately 5% of breast cancers [2].

The mechanism of amyloidogenesis is quite variable, including hereditary mutation, protein overproduction and decreased protein excretion.

The mechanisms of amyloidogenesis in these cases are variable and include abnormal protein production, overproduction or decreased excretion of wild-type proteins and hereditary mutation.

R155 is the most common hereditary mutation and is located in the CDC48 homology domain, which is a protein interaction module that plays an important role in VCP substrate binding (Ju and Weihl, 2010).

In the majority of primary osteosarcomas, the aetiology is unknown, but, for a minority, it occurs in the setting of a previous cancer, such as a hereditary mutation of retinoblastoma or an autosomic recessive mutation of p53 in the Li-Fraumeni syndrome (Huvos et al, 1977; Malkin et al, 1990; Alonso et al, 2001).

Mice carrying a hereditary mutation in the APC gene (min-mice or transgenic ΔAPC-mice; (de Wind et al, 1998) develop a multitude of intestinal polyps in a COX-2 and prostaglandin E2 (PGE2 -receptor-dependent PGE2 -receptor-dependent PGE2 -receptor-dependentayama et al, 2002).