Sentence examples for hereditary alteration from inspiring English sources

These variations do not involve any hereditary alteration and in general are not transmitted to future generations; consequently, they are not significant in the process of evolution.

The mechanism by which this might come about could be a progressive epigenetic hereditary alteration in chromatin organization.

This supposition is sustainable on the basis that in some neoplastic diseases with hereditary predisposition, similar alterations to those observed in this study have been reported in which sequence variants coexist in adjacent or distant genes that promote epigenetic modifications, specifically the methylation in the promoters of specific genes [ 28– 30].

Mutation in the human homologue of the murine progressive ankylosis gene (ANKH) has been reported in patients with hereditary chondrocalcinosis, leading to alteration of the picture of extracellular inorganic pyrophosphate [20].

However, those reports did not compare the frequency of alterations between hereditary and sporadic MSI-H tumors neither the mechanisms that led to HLA class I alterations in each subgroup.

However, the latter studies did not compare the frequency of alterations between hereditary and sporadic MSI-H tumors neither the mechanisms that led to HLA class I alterations in each subgroup.

Some of these alterations are hereditary in nature and have particular relevance for individuals with high-risk family histories, but most are acquired genomic alterations with relevance to all forms of malignancy.

We utilized unique features of LS, including increased tumor incidence and the availability of multiple specimens per individual (normal mucosa, adenoma, and carcinoma, taken at different time points), to gain insights into the role of DNA methylation alterations in hereditary CRC.

A number of hereditary disorders are characterised by alterations of the cell death machinery, as Su and Lenardo nicely illustrate.

Conclusions: The structural alterations found in HGF appear similar to those described in certain other heritable collagen disorders, suggesting that HGF should be included in the group of hereditary diseases in which connective tissue alterations have a distinct pattern, in contrast to reactive fibrotic gingival enlargements with no genetic component.

They are similar to BRCA1 hereditary tumors in their copy number alterations [ 18, 19].