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However, it is possible that androgen deprivation alleviates the repressive role of AR signalling in MET expression and hereby contributes to the metastatic potential of these cells.
40 The observed overactivity of preSMA might therefore constitute an aberrant striatal feedback signal that causes an abnormal induction of internally generated movements and hereby contributes to the emergence of dyskinesias.
A novel finding is that model predictions indicate that the VLDL-CE production rate increases as well (2.5 fold induction) and hereby contributes to the increase of plasma cholesterol levels.
Recently, a new factor in the rapid regulation of Ca2+ homeostasis has been proposed, as fibroblast growth factor 23 (FGF23) was shown to promote renal Ca2+ reabsorption through the TRPV5 channel in the distal tubule, and hereby contributes to conserve Ca. In short time in vitro experiments FGF23 increased the TRPV5 protein abundance and the channel activity already after 45 minutes [ 21].
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Finally in this research we try to increase the understanding of relations between architectural and urban morphology and topography, and hereby contribute to the way we understand cities as responses to social, cultural, functional, natural, and technical conditions in a broader sense as outlined above.
Mechanisms linking a smaller genome to increased fitness may be (i) the potential replicative advantages smaller genomes have over larger genomes, and (ii) reduced expression of redundant protein, leading to more efficient production of virions and hereby contributing to within-host competitive fitness.
Health Impact Assessment (HIA) can be used for this purpose, hereby contributing to informed policymaking and priority setting.
Numerous studies have also suggested that TIDC actively suppress immune responses by potentiating alternative immunosuppressive mechanisms, hereby contributing to tumor escape from immune surveillance [ 8, 18, 21, 23].
Future evaluators could hereby contribute significantly to the understanding of factors associated with the reported effects of clinical pathways in hospitals by incorporating EPOC criteria into study design.
It is of utmost importance to establish information literacy, evidence-based practices, and lifelong learning habits among future physicians early on, hereby contributing to medical education of the highest quality.
These in vitro findings in conjunction with our observations made in cancer tissue specimens suggest that CAR influences gastric cancer cell migration and invasion, hereby contributing to tumour infiltration and dissemination.
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